Creatine

Testosterone and Creatine

In addition to protein synthesis, a rise in androgen levels should also enhance the synthesis of creatine in skeletal muscle tissues. Creatine, as creatine phosphate, plays a crucial role in the manufacture of adenosine triphosphate , which is a main store of energy for the muscles. As the muscle cells are stimulated to contract, ATP molecules are broken down into adenosine diphosphate, which release energy. The cells will then undergo a process using creatine phosphate to rapidly restore ADP to its original structure, in order to replenish ATP concentrations.During period of intense activity however, this process will not be fast enough to compensate and ATP levels will become lowered. This will cause the muscles to become fatigued and less able to effort a strenuous contraction. With increased levels of creatine phosphate available to the cella, ATP is replenished at an enhanced rate and the muscle is both stronger and more enduring. This effect will account for some portion of the early strength increases seen during steroid therapy. Although perhaps not itself technically considered an anabolic effect as tissue hypertrophy is not a direct result, androgen support of creatine synthesis is certainly still looked at as a positive and growth supporting result in the mind of the bodybuilders

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